Vulvar granular cell tumor: a case report
DOI:
https://doi.org/10.47456/rbps.v26isupl_1.44399Keywords:
Granular cell tumor, vulva, granulosa cells, Schwann cellsAbstract
Introduction: Granular cell tumor (GCT) is a mostly benign and rare neoplasm of soft tissues, which can appear in any part of the body but rarely in the vulva. Method and result: This is a case of GCT with one year of evolution in a Brazilian 54-year-old woman, black, diagnosed by biopsy and successfully treated surgically, in addition to a discussion about the findings in the literature. Discussion: GCT is a rare tumor with varied topography and can appear in the female genital tract. Its diagnosis is histopathological and surgical treatment. Objective: Since it is an occasional disease in the clinical practice of Gynecologists, its report is needful to avoid delay in diagnosis or ineffective treatment without evaluating the margin as well as other possible sites of injury. Conclusion: The case reported had therapeutic success made possible by a rapid diagnosis and an investigation of multicentricity and subsequent surgical resection of the lesion with adequate margins.
Downloads
References
Horowitz IR, Copas P, Majmudar B. Granular cell tumors of the vulva. Am J Obstet Gynecol. 1995;173(6):1710-4. doi:10.1016/0002-9378(95)90414-x.
Nagaraj PB, Ongole R, Bhujanga-Rao BR. Granular cell tumor of the tongue in a 6-year-old girl--a case report. Med Oral Patol Oral Cir Bucal. 2006 Mar;11(2):E162-4.
Copas P, Dyer M, Hall DJ, Diddle AW. Granular cell myoblas¬toma of the uterine cervix. Diagn Gynecol Obstet. 1981;3(3):251- 4.
Cheewakriangkrai C, Sharma S, Deeb G, Lele S. A rare female genital tract tumor: benign granular cell tumor of vulva: case report and review of the literature. Gynecol Oncol. 2005;97(2):656-8. doi:10.1016/j.ygyno.2004.12.058.
Kardhashi A, Deliso MA, Renna A, Trojano G, Zito FA, Trojano V. Benign granular cell tumor of the vulva: first report of mul¬tiple cases in a family. Gynecol Obstet Invest. 2012;73(4):341-8. doi:10.1159/000336256.
Robertson AJ, McIntosh W, Lamont P, Guthrie W. Malignant granular cell tumour (myoblastoma) of the vulva: report of a case and review of the literature. Histopathology. 1981;5(1):69- 79. doi:10.1111/j.1365-2559.1981.tb01768.x.
Torrijos-Aguilar A, Alegre-de Miquel V, Pitarch-Bort G, Mer¬cader-García P, Fortea-Baixauli JM. Tumor de células granulares cutáneo: análisis clínico-patológico de treinta y cuatro casos. Actas Dermosifiliogr. 2009;100(2):126-32.
Papalas JA, Shaco-Levy R, Robboy SJ, Selim MA. Isolated and synchronous vulvar granular cell tumors: a clinicopath¬ologic study of 17 cases in 13 patients. Int J Gynecol Pathol. 2010;29(2):173-80. doi:10.1097/PGP.0b013e3181bb4f05.
Ordóñez NG, Mackay B. Granular cell tumor: a review of the pathology and histogenesis. Ultrastruct Pathol. 1999;23(4):207- 22. doi:10.1080/019131299281545.
Schmidt O, Fleckenstein GH, Gunawan B, Füzesi L, Emons G. Recurrence and rapid metastasis formation of a granu¬lar cell tumor of the vulva. Eur J Obstet Gynecol Reprod Biol. 2003;106(2):219-21. doi:10.1016/s0301-2115(02)00165-3.
Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG. Malignant granular cell tumor of soft tissue: diagnostic crite¬ria and clinicopathologic correlation. Am J Surg Pathol. 1998 Jul;22(7):779-94. doi:10.1097/00000478-199807000-00001.
Cui Y, Tong SS, Zhang YH, Li HT. Granular cell tumor: A report of three cases and review of literature. Cancer Biomark. 2018;23(2):173-8. doi:10.3233/CBM-170556.
Kumarapeli AR, Kozielski R. Vulvar atypical granular cell tumor in a preadolescent patient. J Pediatr Adolesc Gynecol. 2013 Jun;26(3):e85-7. doi:10.1016/j.jpag.2013.01.063.
Imanishi J, Yazawa Y, Saito T, et al. Atypical and malignant gran¬ular cell tumors in Japan: a Japanese Musculoskeletal Oncology Group (JMOG) study. Int J Clin Oncol. 2016 Aug;21(4):808-16. doi:10.1007/s10147-016-0949-1.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Brazilian Journal of Health Research

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The Revista Brasileira de Pesquisa em Saúde (RBPS) adopts the CC BY 4.0 license, which means that authors retain the copyright of the works they submit to the journal. Authors are responsible for declaring that their contribution is an original manuscript, that it has not been previously published, and that it is not under simultaneous review by another scientific journal. Upon submitting the manuscript, authors grant RBPS the exclusive right of first publication, subject to peer review.
Authors are permitted to enter into additional contracts for the non-exclusive distribution of the version published by RBPS (for example, in institutional repositories or as a book chapter), provided that due acknowledgment of authorship and of initial publication by RBPS is given. Authors are also encouraged to make their work available online (for example, in institutional repositories or on their personal pages) after its initial publication in the journal, with due acknowledgment of authorship and of the original publication by RBPS.
Accordingly, under the CC BY 4.0 license, readers have the right to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially;
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
The licensor cannot revoke these freedoms as long as you follow the license terms. Under the following terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.