Temporal analysis of mortality from urolithiasis in Brazil (2013-2023)

an ecological study using DATASUS data

Authors

DOI:

https://doi.org/10.47456/rbps.v27i1.50632

Keywords:

Urolithiasis, Mortality, Epidemiology, Brazil, Public health

Abstract

Introduction: Urinary lithiasis results from salt aggregation in urine, referred to as nephrolithiasis when located in the kidneys and urolithiasis when present in the urinary tract. In Brazil, although epidemiological data are publicly available, no study has characterized mortality from urinary lithiasis, resulting in a gap in knowledge on this topic. Objectives: To perform an epidemiological and temporal analysis of overall and proportional mortality rates from urinary lithiasis in Brazil from 2013 to 2023, using DATASUS secondary data. Methods: This retrospective observational study used data from the Mortality Information System (SIM/DATASUS) covering the period from 2013 to 2023. Deaths caused by urinary lithiasis (ICD-10: N20 to N23) were included, and analyses were performed according to sex, age, race/skin color, and region. General and proportional mortality rates were calculated using annual population estimates from the Brazilian Institute of Geography and Statistics (IBGE). Results: The highest mortality rates due to lithiasis were observed among women, white individuals, with an average age of 67 years. Temporal changes in lithiasis mortality were observed over the 10-year period; on average, there were 0.09 deaths per 100,000 inhabitants, and the proportional mortality rate was 0.01% (1 in 10,000 deaths). Conclusion: Although urinary lithiasis accounts for only 0.01% of registered deaths, it is a preventable cause with appropriate treatment. Given its significant risk for complications such as sepsis, especially in older adults and individuals with comorbidities, the true mortality from lithiasis is likely underestimated in the available data.

Downloads

Download data is not yet available.

References

Stamatelou K, Goldfarb DS. Epidemiology of kidney stones. Healthcare (Basel). 2023;11(3):424.

Wang Z, Zhang Y, Zhang J, Deng Q, Liang H. Recent advances on the mechanisms of kidney stone formation (Review). Int J Mol Med. 2021;48(2):149.

Brito PRS, Silva RM, Brito NCS, Silva NA, Pereira LPS, Morais SAA, et al. Litíase renal: uma visão abrangente da composição e modalidades terapêuticas. Braz J Implantol Health Sci. 2024;6(4):799-809.

Kachkoul R, Touimi GB, El Mouhri G, El Habbani R, Mohim M, Lahrichi A. Urolithiasis: history, epidemiology, aetiologic factors and management. Malays J Pathol. 2023;45(3):333-352.

Allam EAH. Urolithiasis unveiled: pathophysiology, stone dynamics, types, and inhibitory mechanisms: a review. Afr J Urol. 2024;30(1):40.

Wang K, Ge J, Han W, Wang D, Zhao Y, Shen Y, et al. Risk factors for kidney stone disease recurrence: a comprehensive meta-analysis. BMC Urol. 2022;22(1):62.

Peerapen P, Thongboonkerd V. Kidney stone prevention. Adv Nutr. 2023;14(3):555-569.

Ferraro PM, Curhan GC, Gambaro G, Taylor EN. Total, dietary, and supplemental vitamin C intake and risk of incident kidney stones. Am J Kidney Dis. 2016;67(3):400-407.

Kemble JP, Liaw CW, Alamiri JM, Ungerer GN, Potretzke AM, Koo K. Public interest in vitamin C supplementation during the COVID-19 pandemic as a potential risk for oxalate nephrolithiasis. Cureus. 2025;17(2):e79452.

Carvalho M, Matos ACC, Santos DR, Barreto DV, Barreto FC, Rodrigues FG, et al. Diretrizes Brasileiras para diagnóstico e tratamento clínico da Nefrolitíase: Sociedade Brasileira de Nefrologia. J Bras Nefrol. 2025;47(2):e20240189.

Sun Y, Xu F, Xiao Z, An Y, Zhao H. Risk factor analysis and predictive modeling of kidney stone disease in the United States population: a propensity score matching cohort study. Actas Urol Esp (Engl Ed). 2025;49(3):501715.

Abreu Júnior J, Ferreira Filho SR. Influence of climate on the number of hospitalizations for nephrolithiasis in urban regions in Brazil. J Bras Nefrol. 2020;42(2):175-181.

Instituto Brasileiro de Geografia e Estatística. IBGE divulga sub-registros e subnotificações de nascimentos e óbitos de 2022 [Internet]. Rio de Janeiro: Agência de Notícias do IBGE; 2024 abr 4 [citado 2025 jun 12]. Disponível em: https://agenciadenoticias.ibge.gov.br/agencia-noticias/2012-agencia-de-noticias/noticias/39647-ibge-divulga-sub-registros-e-subnotificacoes-de-nascimentos-e-obitos-de-2022

Silva SFR, Silva SL, Campos HH, Daher EDF, Silva CAB. Dados demográficos, clínicos e laboratoriais de pacientes com litíase urinária em Fortaleza, Ceará. J Bras Nefrol. 2011;33(3):295-299.

Sorokin I, Mamoulakis C, Miyazawa K, Rodgers A, Talati J, Lotan Y. Epidemiology of stone disease across the world. World J Urol. 2017;35(9):1301-1320.

Chien TM, Lu YM, Li CC, Wu WJ, Chang HW, Chou YH. A retrospective study on sex difference in patients with urolithiasis: who is more vulnerable to chronic kidney disease? Biol Sex Differ. 2021;12(1):40.

Wood B, Habashy D, Mayne DJ, Dhar A, Purvis C, Skyring T. The utility of preoperative and intraoperative cultures for guiding urosepsis empirical treatment. J Clin Urol. 2020;13(2):132-139.

Chewcharat A, Curhan G. Trends in the prevalence of kidney stones in the United States from 2007 to 2016. Urolithiasis. 2021;49(1):27-39.

Wang Z, Zhang Y, Wei W. Effect of dietary treatment and fluid intake on the prevention of recurrent calcium stones and changes in urine composition: a meta-analysis and systematic review. PLoS One. 2021;16(4):e0250257.

Tan RYP, Rao NN, Horwood CM, Passaris G, Juneja R. Recurrent nephrolithiasis and loss of kidney function: a cohort study. Int Urol Nephrol. 2023;55(6):1539-1547.

Instituto Brasileiro de Geografia e Estatística. Desigualdades sociais por cor ou raça no Brasil. 2ª ed. Rio de Janeiro: IBGE; 2022 [citado 2025 jun 9]. (Estudos e Pesquisas – Informação Demográfica e Socioeconômica). Disponível em: https://biblioteca.ibge.gov.br/visualizacao/livros/liv101972_informativo.pdf

Romero DE, Maia L, Muzy J. Tendência e desigualdade na completude da informação sobre raça/cor dos óbitos de idosos no Sistema de Informações sobre Mortalidade no Brasil, entre 2000 e 2015. Cad Saude Publica. 2019;35(12):e00223218.

Instituto Brasileiro de Geografia e Estatística. Em 2021, número de óbitos bate recorde de 2020 e número de nascimentos é o menor da série [Internet]. Rio de Janeiro: Agência de Notícias do IBGE; 2023 fev 16 [citado 2025 jun 12]. Disponível em: https://agenciadenoticias.ibge.gov.br/agencia-noticias/2012-agencia-de-noticias/noticias/36308-em-2021-numero-de-obitos-bate-recorde-de-2020-e-numero-de-nascimentos-e-o-menor-da-serie

Szwarcwald CL, Souza Júnior PRB, Damacena GN, et al. ConVid – Pesquisa de Comportamentos pela Internet durante a pandemia de COVID-19 no Brasil: concepção e metodologia de aplicação. Cad Saude Publica. 2021;37(3):e00268320.

Canhada SL, Luft VC, Giatti L, et al. Ultra-processed foods, incident overweight and obesity, and longitudinal changes in weight and waist circumference: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Public Health Nutr. 2020;23(6):1076-1086.

Mill JG, Malta DC, Nilson EAF, et al. Fatores associados ao consumo de sal na população adulta brasileira: Pesquisa Nacional de Saúde. Cien Saude Colet. 2021;26(2):555-567.

Tsuchiya T, Taito K, Ota Y, et al. Risk factors for septic shock in older patients with urinary tract infection. Clin Exp Nephrol. 2025;29(3):368-375.

Published

2025-12-31

Issue

Section

Artigos Originais

How to Cite

1.
Temporal analysis of mortality from urolithiasis in Brazil (2013-2023): an ecological study using DATASUS data. RBPS [Internet]. 2025 Dec. 31 [cited 2026 Aug. 4];27(1):e50632. Available from: https://periodicos.ufes.br/rbps/article/view/50632