Efeito da aplicação de resveratrol tópico em indivíduos com sinais de envelhecimento cutâneo: uma revisão sistemática

Effect of topical resveratrol application in individuals with signs of skin aging: a systematic review

Abstract

The skin age is accompanied by elasticity decrease, which results in flaccidity, fine and deep wrinkles besides dehydration. This process can be accompanied by a gradual decrease in melanocytes number, associated by an irregular increase of melanogenesis activity, which results in discromias disorder as hypo or hyperpigmentation. The interest in new substances with skin rejuvenation properties, especially from natural sources, has increased in the last years. In this way, resveratrol (3,4’,5-trihydroxy-trans-stilbene) is a natural substance and has been increasingly in the cosmetic industry because of its antioxidant, anti inflammatory and despigmenting properties. The aim of this systematic review was to analyze the potential of resveratrol in promoting skin rejuvenation.  Medline and Embase were searched for studies that tested topical formulation with resveratrol in humans and measured the efficacy in skin rejuvenation. Two studies fulfilled the criteria of inclusion. In both studies the authors observed improvement in the global appearance, accompanied by improvement in fine lines, shine, firmless, redness and pigmentation. Despite both studies showed the benefits of topical resveratrol, none of them used the substance alone.