Análise das manifestações otorrinolaringológicas da doença do refluxo gastroesofágico em pacientes atendidos em uma unidade de referência em Imperatriz-MA

Arthur Rickson Nunes Dias; Fabricio Leocadio Rodrigues de Sousa; Marcos Antonio Custodio Neto da Silva

doi:10.47456/rbps.v25i2.40595

Authors

Arthur Rickson Nunes Dias Universidade Federal do Maranhão https://orcid.org/0000-0002-8840-1700
Fabricio Leocadio Rodrigues de Sousa https://orcid.org/0000-0002-2291-1812
Marcos Antonio Custodio Neto da Silva Universidade Federal do Maranhão https://orcid.org/0000-0003-2748-1564

DOI:

https://doi.org/10.47456/rbps.v25i2.40595

Keywords:

Gastroesophageal Reflux, Signs and Symptoms, Key Symptoms, Otolaryngology

Abstract

Introduction: Gastroesophageal reflux disease covers a wide spectrum of disorders related to the return of gastric contents to the esophagus. The presence of extraesophageal manifestations may be suspected in patients with otorhinolaryngological manifestations, such as unexplained chronic cough and laryngopharyngeal symptoms. Objective: To analyze the clinical-epidemiological profile of otorhinolaryngological manifestations in patients diagnosed with gastroesophageal reflux disease in a reference unit in the south of Maranhão. Methodology: The study is configured as a field, descriptive, analytical and cross-sectional research carried out through the application of a questionnaire to patients treated at a reference clinic in otorhinolaryngology in Imperatriz-MA. The collection took place through the survey of clinical and epidemiological information of patients identified with reflux disease and admitted to the clinic based on the validated questionnaire and an adapted script. Results: 24 patients (72.7%) were more likely to have laryngopharyngeal reflux. The main symptom reported was heartburn/regurgitation in 28 patients (84.8%), followed by pharyngeal globus (78.8%). By correlating the BMI with the scores obtained in the questionnaire, a progression in the intensity of the symptoms was observed: excess secretion in the throat, irritating cough, sensation of a lump in the throat and heartburn. Conclusion: Faced with a large spectrum of described manifestations, the heterogeneity of disease symptoms was observed. Subtle correlations were observed in the 50-59 age group, smokers and with a BMI of 25-29.9 kg/m².

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Author Biographies

Fabricio Leocadio Rodrigues de Sousa

Possui graduação em Medicina pela Universidade Federal do Pará (2012). Tem experiência na área de Medicina, com ênfase em otorrinolaringologia

Marcos Antonio Custodio Neto da Silva, Universidade Federal do Maranhão

Médico, graduado pela Universidade Federal do Maranhão (2017). Doutor em Clínica Médica pela Faculdade de Ciências Médicas da Unicamp (2022) Gastroenterologista pelo Hospital Universitário da Universidade Federal do Maranhão (2022) Professor e Coordenador do Curso de Medicina do Centro de Ciências de Imperatriz da Universidade Federal do Maranhão em Imperatriz Atuo em pesquisas básicas e clínicas nas áreas de Gastroentrologia, Oncologia e Farmacologia, com objetivo de desenvolvimento de compostos fármaco-ativos derivados de produtos naturais.

References

Hunt R, Armstrong D, Katelaris P, Afihene M, Bane A, Bhatia S, et al. World Gastroenterology Organisation Global Guidelines: GERD Global Perspective on Gastroesophagel Reflux Disease. J Clin Gastroenterol. 2017; 51(6):467-478.

Meira AT, Tanajura D, Viana ID. Clinical And Endoscopic Eval¬uation In Patients With Gastroesophageal Symptoms. Arq Gas¬troenterol. 2019; 56(1):51-54.

Coronel MA, Bernardo WM, Moura DT, Moura ET, Ribeiro IB, Moura EG. The efficacy of the different endoscopic treatments versus sham, pharmacologic or surgical methods for chronic gastroesophageal reflux disease: a systematic review and meta-analysis. Arq Gastroenterol. 2018; 55(3):296-305.

Xiao S, Li J, Zheng H, Yan Y, Li X, Zhang L, et al. An epidemio¬logical survey of laryngopharyngeal reflux disease at the otorhi¬nolaryngology-head and neck surgery clinics in China. Eur Arch Otorhinolaryngol. 2020; 277(10):2829-2838.

Hom C, Vaezi MF. Extra-esophageal manifestations of gastro¬esophageal reflux disease: diagnosis and treatment. Drugs. 2013; 73(12):1281-1295.

Gurski RR, Rosa AR, Valle E, Borba MA, Valiati AA. Manifes¬tações extra-esofágicas da doença do refluxo gastroesofágico. J Bras Pneumol. 2006; 32(2):150-160.

Junior A, João L. Doença do refluxo gastroesofágico. J Bras Med. 2014; 102(6):31-36.

Eusebi LH, Ratnakumaran R, Yuan Y, Solaymani-Dodaran M, Bazzoli F, Ford AC. Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: a meta-analysis. Gut. 2018; 67(3):430-440.

Ferreira AP de S, Szwarcwald CL, Damacena GN, Souza Júnior PR de. Increasing trends in obesity prevalence from 2013 to 2019 and associated factors in Brazil. Rev bras epidemiol. 2021; 24(3):87-91.

Eckley CA, Tangerina R. Sensitivity, Specificity, and Reproduc¬ibility of the Brazilian Portuguese Version of the Reflux Symp¬tom Index. J Voice. 2021 Jan;35(1): 161.e15-161.e19.

Manabe N, Tsutsui H, Kusunoki H, Hata J, Haruma K. Patho¬physiology and treatment of patients with globus sensa¬tion--from the viewpoint of esophageal motility dysfunction. J Smooth Muscle Res. 2014; 50(2):66-77.

Reulbach TR, Belafsky PC, Blalock PD, Koufman JA, Postma GN. Occult laryngeal pathology in a community-based cohort. Otolaryngol Head Neck Surg. 2001; 124(4):448-450.

Lechien JR, Bobin F, Muls V, Saussez S, Hans S. Laryngopharyn¬geal Reflux Disease is More Severe in Obese Patients: A Prospec¬tive Multicenter Study. Laryngoscope. 2021; 131(11):2742-2748.

Akinola MA, Oyedele TA, Akande KO, Oluyemi OY, Salami OF, Adesina AM, et al. Gastroesophageal reflux disease: prev¬alence and Extraesophageal manifestations among undergradu¬ate students in South West Nigeria. BMC GastroenteroL. 2020; 26(20):64-69.

Mansour-Ghanaei F, Joukar F, Atshani SM, Chagharvand S, Souti F. The epidemiology of gastroesophageal reflux disease: a survey on the prevalence and the associated factors in a random sample of the general population in the Northern part of Iran. Int J Mol Epidemiol Genet. 2013; 4(3):175-82.

Ehsani MJ, Maleki I, Mohammadzadeh F, Mashayekh A. Epi¬demiology of gastroesophageal reflux disease in Tehran, Iran. J Gastroenterol Hepatol. 2007; 22(9):1419-1422.

Spantideas N, Drosou E, Bougea A, Assimakopoulos D. Laryn¬gopharyngeal reflux disease in the Greek general population, prevalence and risk factors. BMC Ear Nose Throat Disord. 2015; 15(1):1-7.

Kouklakis G, Moschos J, Kountouras J, Mpoumponaris A, Moly¬vas E, Minopoulos G. Relationship between obesity and gastro¬esophageal reflux disease as recorded by 3-hour esophageal pH monitoring. Rom J Gastroenterol. 2005;1 4(2):117-121.

Min YW, Lim SW, Lee JH, Lee HL, Lee OY, Park JM, Choi MG, Rhee PL. Prevalence of Extraesophageal Symptoms in Patients With Gastroesophageal Reflux Disease: A Multicenter Ques¬tionnaire-based Study in Korea. J Neurogastroenterol Motil. 2014; 20(1):87-93.