Impactos da diabetes mellitus na COVID-19: uma revisão da literatura

Ana Dária  Cassoli da Silva; Stela  Steiner Cibien; Lorena Carnielli Queiroz; Dyego Carlos  Souza Anacleto de Araujo; Lorena  Rocha Ayres; Barbara Juliana Pinheiro Borges; Daniela  Amorim Melgaço Guimarães do Bem

Autores

Ana Dária Cassoli da Silva https://orcid.org/0000-0002-5056-8089
Stela Steiner Cibien https://orcid.org/0000-0002-5622-6936
Lorena Carnielli Queiroz Universidade Federal do Espírito Santo https://orcid.org/0000-0002-3834-8358
Dyego Carlos Souza Anacleto de Araujo https://orcid.org/0000-0001-6631-465X
Lorena Rocha Ayres https://orcid.org/0000-0003-4346-5281
Barbara Juliana Pinheiro Borges https://orcid.org/0000-0002-8553-8306
Daniela Amorim Melgaço Guimarães do Bem https://orcid.org/0000-0001-9296-7486

Palavras-chave:

Pandemia, COVID-19, SARS-CoV-2, Complicações diabéticas, SRDA humano

Resumo

Introdução: Desde o início da pandemia avalia-se a correlação entre a diabetes mellitus e o agravamento dos casos de COVID-19, uma vez que pacientes infectados pelo SARS-CoV-2 possuem taxa de hospitalização, pneumonia grave e mortalidade mais elevada. Objetivo: O estudo buscou compreender e verificar a correlação da diabetes mellitus com os desfechos agravantes da COVID-19. Métodos: Foi realizada revisão bibliográfica narrativa por meio de leitura exploratória e seletiva de artigos e, por fim, registro das informações relevantes. Utilizou-se como fonte de pesquisa a base de dados PUBMED e Google Scholar, entre 2000 a 2022, com as palavras-chave: Diabetes Mellitus, COVID-19, pandemia por COVID-19, infecção por SARS-CoV-2, SARS-CoV-2, infecção viral COVID-19, coronavírus da síndrome respiratória do oriente médio, SRDA humana. Resultados e discussão: Os artigos mostraram que a associação entre diabetes mellitus e COVID-19 leva a um aumento do risco de duas vezes na mortalidade e na gravidade do COVID-19. Além disso, há o desenvolvimento de complicações como disfunção endotelial e alveolar, hipercoagulação, bem como resposta imune desregulada que colaboram para desfechos graves. Conclusão: A diabetes mellitus contribui para um mau prognóstico e desfechos agravantes dos casos de COVID-19, entretanto estudos são necessários para elucidar os mecanismos associados a essas doenças.

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Referências

Mohamadian M, Chiti H, Shoghli A, Biglari S, Parsamanesh N, Esmaeilzadeh A. COVID-19: virology, biology and novel laboratory diagnosis. J Gene Med. 2021;23(2):1-11.

Harrison AG, Lin T, Wang P. Mechanisms of SARS-CoV-2 transmission and pathogenesis. Trends Immunol. 2020;41(12):1100-15.

Ahirwar R, Gandhi S, Komal K, Dhaniya G, Tripathi PP, Shingatgeri VM, Kumar, K, Shama, JG, Kumar, S. Biochemical composition, transmission and diagnosis of SARS-CoV-2. Biosci Rep. 2021;41(8):1-18.

Majumder J, Minko T. Recent developments on therapeutic and diagnostic approaches for COVID-19. AAPS J. 2021;23(1).

Cheung KS, Hung IF, Chan PP, Lung KC, Tso E, Liu R et al. Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from a Hong Kong cohort: systematic review and meta-analysis. Gastroenterology. 2020;159:81-95.

Salian VS, Wright JA, Vedell PT, Nair S, Li C, Kandimalla M et al. COVID-19: transmission, current treatment, and future therapeutic strategies. Mol Pharm. 2021;18(3):754- 71.

Lima-Martínez MM, Carrera Boada C, Madera-Silva MD, Marín W, Contreras M. COVID-19 y diabetes mellitus: una relación bidireccional. Clin e Investig en Arterioscler. 2021;33(3):151-7.

Ejaz H, Alsrhani A, Zafar A, Javed H, Junaid K. COVID-19 and comorbidities: deleterious impact on infected patients. J Infect Public Health. 2020;13:1833-9.

Harreiter J, Roden M. Diabetes mellitus: definition, classification, diagnosis, screening and prevention (Update 2019). Wien Klin Wochenschr. 2019;131:6-15.

Kumar A, Arora A, Sharma P, Anil S. Is diabetes mellitus associated with mortality and severity of COVID- 19? A meta-analysis. Diabetes Metab Syndr Clin Res Rev. 2020;14:535-45.

Guo W, Li M, Dong Y, Zhou H, Zhang Z, Tian C et al. Diabetes is a risk factor for the progression and prognosis of COVID-19. Diabetes Metab Res Rev. 2020;36 (7):1-9.

Landstra CP, de Koning EJ. COVID-19 and diabetes: understanding the interrelationship and risks for a severe course. Front Endocrinol (Lausanne). 2021;12:1-18.

Fleury MK. A COVID-19 e o laboratório de hematologia: uma revisão da literatura recente. Rev Bras Análises Clínicas. 2020;52(2):131-7.

Ciaccio M, Agnello L. Biochemical biomarkers alterations in coronavirus disease 2019 (COVID-19). Diagnosis. 2020;7(4):365-72.

Anghebem MI, Rego FG, Picheth G. COVID-19 e diabetes: a relação entre duas pandemias distintas. Rev Bras Análises Clínicas. 2020;52(2):28-33.

Khan M, Syed FA, Hamad ZA, Muhammad NT, Saif S, Khan ST. Epidemiology and progress so far. Molecules. 2021;26 (1):1-25.

Yesudhas D, Srivastava A, Gromiha MM. COVID-19 outbreak: history, mechanism, transmission, structural studies and therapeutics. Infection. 2021;49(2):199-213.

Huang X, Dong W, Milewska A, Golda A, Qi Y, Zhu QK et al. Human Coronavirus HKU1 spike protein uses o-acetylated sialic acid as an attachment receptor determinant and employs hemagglutinin-esterase protein as a receptor-destroying enzyme. J Virol. 2015;89(14):7202- 13.

Hofmann H, Pöhlmann S. Cellular entry of the SARS coronavirus. Trends Microbiol. 2004;12(10):466-72.

Chung JY, Thone MN, Kwon YJ. COVID-19 vaccines: the status and perspectives in delivery points of view. Adv Drug Deliv Rev. 2020;170:1-25.

Sette A, Crotty S. Adaptive immunity to SARS-CoV-2 and COVID-19 Alessandro. Cell. 2021;184:861-80.

Grudzien M, Rapak A. Effect of natural compounds on NK cell activation. J Immunol Res. 2018.

Anka AU, Tahir MI, Abubakar SD, Alsabbagh M, Zian Z, Hamedifar H et al. Coronavirus disease 2019 (COVID-19): an overview of the immunopathology, serological diagnosis and management. Scand J Immunol. 2020;93(4):1-12.

Coomes EA, Haghbayan H. Interleukin-6 in Covid-19: a systematic review and meta-analysis. Rev Med Virol. 2020;30(6):1-9.

Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H et al. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest. 2020;130(5):2620-9.

Mudatsir M, Fajar JK, Wulandari L, Soegiarto G, Ilmawan M, Purnamasari Y et al. Predictors of COVID-19 severity: a systematic review and meta-analysis. F1000b Research. 2021;9:1-26.

South AM, Diz DI, Chappell MC. COVID-19, ACE2, and the cardiovascular consequences. Am J Physiol Hear Circ. 2020.

Li J, Huang DQ, Zou B, Yang H, Hui WZ, Rui F et al. Epidemiology of COVID-19: a systematic review and meta-analysis of clinical characteristics, risk factors, and outcomes. J Med Virol. 2021;93(3):1449-58.

Rachdaoui N. Insulin: the friend and the foe in the development of type 2 diabetes mellitus. Int J Mol Sci. 2020;21(5):1-21.

Schmidt AM. Highlighting diabetes: the epidemic continues. Physiol Behav. 2016;176(1):139-48.

Kumar V, Abbas AK, Aster JC. Robbins patologia básica. 10a. GEN; 2018. 952 p.

Erener S. Diabetes, infection risk and COVID-19. Molec Metabolism. 2020;39:1010-44.

Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271-80.

Rao S, Lau A, So HC. Exploring diseases/traits and blood proteins causally related to expression of ACE2, the putative receptor of SARS-CoV-2: A mendelian randomization analysis highlights tentative relevance of diabetes-related traits. Diabetes Care. 2020;43(7):1416-26.

Chakraborty C, Sharma AR, Bhattacharya M, Sharma G, Agoramoorthy G, Lee SS. Diabetes and COVID-19: a major challenge in pandemic period? Eur Rev Med Pharmacol Sci. 2020;24(21):11409-20.

Rajendran P, Rengarajan T, Thangavel J, Nishigaki Y, Sakthisekaran D, Sethi G et al. The vascular endothelium and human diseases. Int J Biol Sci. 2013;9(10):1057-69.

Orshal JM, Khalil RA. Gender, sex hormones, and vascular tone. Am J Physiol Regul Integr Comp Physiol. 2004; 286 p.

Sobel BE, Schneider DJ. Platelet function, coagulopathy and impaired fibrinolysis in diabetes. Cardiol Clin. 2004;22:511-26.

Antoniak S. The coagulation system in host defense. Res Pract Thromb Haemost. 2018;2(3):549-57.

Anandhalakshmi S, Manikandan S, Ganeshkumar P, Ramachandran C. Alveolar gas exchange and pulmonary functions in patients with type II diabetes mellitus. J Clin Diagnostic Res. 2013;7(9):1874-7.

EBC. Empresa brasileira de comunicação. Mortalidade pela COVID-19 é 57% maior em pacientes com diabetes. 2021. Disponível em: https://radios.ebc.com.br/tarde-nacional/2021/04/mortalidade-por-covid-19-e-57-maior-em-pacientes-com-diabetes. Acesso em: 6. fev. 2022.

Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z et al. Clinical course and risk factors for mortality of adult in patients with COVID-19. In: Wuhan, China: a retrospective cohort study. J Med Study Res. 2020;395(1):1054-62.

Varikasuvu SR, Dutt N, Thangappazham B, Varshney S. Diabetes and COVID-19: a pooled analysis related to disease severity and mortality. Prim Care Diabetes. 2020;15:24-7.

Wang W, Lu J, Gu W, Zhang Y, Liu J, Ning G. Care for diabetes with COVID-19: Advice from China. J Diabetes. 2020;12(5):417-9.

Bornstein SR, Gallwitz B, Kellerer M, Ludwig B, Müller- Wieland D, Neu A et al. Practical recommendations of the German Diabetes Society for the management of diabetes in patients with COVID-19. Lancet Diabetes Endocrino. 2020;8(1):546-50.

Huang I, Lim MA, Pranata R. Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia e a systematic review, meta-analysis, and meta-regression. Ann Oncol. 2020;19-22.

Aggarwal G, Lippi G, Lavie CJ, Henry BM, Sanchis- Gomar F. Diabetes mellitus association with coronavirus disease 2019 (COVID-19) severity and mortality: a pooled analysis. J Diabetes. 2020;12(11):851-5.

De Almeida-Pititto B, Dualib PM, Zajdenverg L, Dantas JR, De Souza FD, Rodacki M et al. Severity and mortality of COVID 19 in patients with diabetes, hypertension and cardiovascular disease: a meta-analysis. Diabetol Metab Syndr. 2020;12:1-12.

Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern. Med. 2020;180(7):934-43.