Impacto dos Inibidores de SGLT2 na insuficiência cardíaca e doença renal crônica: revisão integrativa

Rodrigo Mazzini Calmon Alves; Mario Sergio Zen

doi:10.47456/rbps.v26isupl_3.16

Autores/as

Rodrigo Mazzini Calmon Alves Universidade Federal do Espírito Santo
Mario Sergio Zen Universidade Federal do Espírito Santo

DOI:

https://doi.org/10.47456/rbps.v26isupl_3.16

Palabras clave:

ISGLT, Diabetes Mellitus, Doença renal crônica, Insuficiência cardíaca

Resumen

Introdução: Os inibidores do cotransportador de sódio e glicose são fármacos inicialmente desenvolvidos para tratamento do diabetes mellitus tipo 2, entretanto, foi rapidamente descoberto o potencial de benefício cardiovascular e renal pelos seus efeitos diretos e pleiotrópicos. Objetivos: Discutir os principais ensaios clínicos acerca do tema. Métodos: Foi realizado busca nas bases de dados PubMed/Medline, utilizando os termos "SGLT2 inhibitors", "heart failure", "chronic kidney disease", combinados por operadores booleanos como “AND” e “OR”. Os critérios de inclusão foram: artigos em inglês, estudos publicados entre janeiro de 2015 e dezembro de 2022, ensaios clínicos randomizados, amostra maior que 3500 indivíduos. foram excluídos estudos com Sotagliflozina e Ertugliflozina pela indisponibilidade no Brasil das medicações. Os estudos foram avaliados por dois pesquisadores. Foram incluídos 11 estudos de uma amostra inicial de 99. Resultados: Foi observado que os Inibidores de SGLT-2 são benéficos no tratamento de Insuficiência cardíaca e Doença renal crônica. Conclusão: Os inibidores do SGLT-2 são uma importante adição às possibilidades de tratamento de pacientes com insuficiência cardíaca e doença renal crônica, além disso, o potencial da classe ainda está sendo estudado e as indicações podem ser ampliadas nos próximos anos.

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