Technical-economic evaluation of the implementation of an integrated ethanol biorefinery: literature review

Authors

DOI:

https://doi.org/10.21712/lajer.2025.v12.n3.p83-92

Keywords:

Simulation, Bibliometrics , biomass

Abstract

 In Brazil, ethanol is a fuel produced in sugarcane biorefineries that generate sugar, ethanol and bioelectricity. The full use of the residual lignocellulosic biomass generated in these facilities can contribute to increasing ethanol production, although the relatively high costs of installing and operating second-generation ethanol production lines are still an obstacle. Thus, the objective of the present work was to perform a bibliographic review of publications on the simulation of integrated ethanol production processes in sugarcane biorefinery. To perform a bibliometrics of relevant publications on this topic, two scientific databases were consulted and the publications were selected by the date of publication, by the average number of annual citations and by the analysis of the expanded abstracts. The metadata of the selected publications were used for the scientific mapping carried out in the Bibliometrix software. Regarding the results of the bibliometric analysis, 152 publications were found and an annual growth rate of publications equal to 12.6% was observed. Most of the most productive authors in this research section are Brazilian and are associated with Brazilian universities and research institutions. From the literature review carried out, it was concluded that most of the feasibility analysis of sugarcane ethanol biorefinery projects are carried out in the Aspen Plus process simulator, combined with the use of electronic spreadsheets. In the selected studies, there is a consensus that the integrated production of ethanol presents higher productivity when compared to the autonomous operation of first-generation ethanol, although the technical difficulties of the production of second-generation ethanol still reside in the pre-treatment and enzymatic hydrolysis stages. As the main methodologies for the economic evaluation of ethanol biorefinery installation projects, the internal rate of return (IRR) and the evaluation of the cost of capital associated with the ethanol sale price stand out.

Downloads

Download data is not yet available.

Author Biographies

  • Julio Pansiere Zavarise, UFES

    PhD candidate in Energy at PPGEN/UFES. Master's degree in Energy from the Postgraduate Program in Energy (PPGEN) at the Federal University of Espírito Santo (UFES) and Bachelor's degree in Chemical Engineering from UFES.

  • Maristela de Araujo Vicente, UFES

    She holds a degree in Pharmacy from the Federal University of Ouro Preto (1992), a master's degree in Biological Sciences from the Federal University of Ouro Preto (2003), and a doctorate in Biological Sciences from the Federal University of Ouro Preto (2007). She is currently an Adjunct Professor III at the Federal University of Espírito Santo, located in the Department of Natural Sciences. She teaches Analytical Chemistry and Instrumental Analysis. She has experience in the field of Analytical Chemistry, with an emphasis on Analytical Instrumentation, mainly working on the following topics: sample preparation, petroleum, ultrasound, water, and remediation. She holds 3 national innovation patents.

  • Fabio de Assis Ressel Pereira, UFES

    Doctor of Chemical Engineering from the Federal University of Uberlândia (2006). Currently an Adjunct Professor at the Federal University of Espírito Santo, in the Department of Industrial Technology. Permanent professor in the Postgraduate Program in Energy, developing teaching and research activities in the areas of Well Technology and Flow Assurance.

  • Laura Marina Pinotti, UFES

    She holds a degree in Chemical Engineering from the Federal University of Rio Grande (1996), a master's degree in Chemical Engineering from the Federal University of São Carlos (1999), a doctorate in Chemical Engineering from the Federal University of São Carlos (2003), with a sandwich doctorate at the Instituto Superior Técnico of the Technical University of Lisbon, and postdoctoral studies in Molecular Biology at the Center for Biological and Health Sciences of the Federal University of São Carlos and in Enzyme Purification and Immobilization at the Instituto de Investigación en Ciencias de la Alimentacion (CIAL) - Universidad Autónoma de Madrid. Currently, she is a professor at the Federal University of Espírito Santo and a permanent member of the PPGEN, Master's program in Energy, in the research area of ​​Petroleum, Gas and Renewable Energies. She has experience in Chemical Engineering in the area of ​​Biochemistry - Biotechnology with an emphasis on the production, purification, immobilization and cloning of enzymes. She is currently developing research projects mainly in obtaining biofuels and in the production of enzymes used in these processes.

References

Aguiar, DR, Taheripour, F e Silva, DA (2025) ‘Ethanol fuel in Brazil: Policies and carbon emission avoidance’, Biofuels, 16(3), pp. 248-258.

Albarelli, JQ (2013) Produção de açúcar e etanol de primeira e segunda geração: simulação, integração energética e análise econômica. [Tese de Doutorado, Universidade Estadual de Campinas (UNICAMP)].

Andrade Junior, MAU et al. (2019) ‘Exploring future scenarios of ethanol demand in Brazil and their land-use implications’, Energy Policy, 134, p.110958.

Bonomi, A et al. (2016) Virtual biorefinery. Cham: Springer International Publishing.

Conteratto, C et al. (2021) ‘Biorefinery: A comprehensive concept for the sociotechnical transition toward bioeconomy’, Renewable and Sustainable Energy Reviews, 151, p.111527.

Correa, C et al. (2023) ‘Brazil and the world market in the development of technologies for the production of second-generation ethanol’, Alexandria Engineering Journal, 67, pp.153-170.

CTBE – Laboratório Nacional de Ciência e Tecnologia do Bioetanol (2012) The Virtual Sugacane Biorefinery - 2011 Report. Relatório Técnico.

Dias, MO et al. (2013) ‘Cogeneration in integrated first and second generation ethanol from sugarcane’, Chemical Engineering Research and Design, 91(8), pp.1411-1417.

Donthu, N et al. (2021) ‘How to conduct a bibliometric analysis: An overview and guidelines’, Journal of Business Research, 133, pp.285-296.

Empresa de Pesquisa Energética (2025) Balanço Energético Nacional. Relatório Síntese. Disponível em: https://www.epe.gov.br/sites-pt/publicacoes-dados-abertos/publicacoes/PublicacoesArquivos/publicacao-819/topico-723/BEN2024.pdf (Acesso: 04 Setembro 2025).

Energy Institute (2024) Statistical Review of World Energy. Disponível em: https://www.energyinst.org/statistical-review/ (Acesso: 06 Outubro 2025).

Garcia, TC et al. (2022) ‘Consumers’ willingness to pay for second-generation ethanol in Brazil’, Energy Policy, 161, p.112729.

Hoang, TD e Nghiem, N (2021) ‘Recent developments and current status of commercial production of fuel ethanol’, Fermentation, 7(4), p.314.

Karp, SG et al. (2021) ‘Bioeconomy and biofuels: the case of sugarcane ethanol in Brazil’, Biofuels, Bioproducts and Biorefining, 15(3), pp.899-912.

Mendes, FM et al. (2017) ‘Techno-economic impacts of varied compositional profiles of sugarcane experimental hybrids on a biorefinery producing sugar, ethanol and electricity’, Chemical Engineering Research and Design, 125, pp.72-78.

Mizik, T (2021) ‘Economic aspects and sustainability of ethanol production—a systematic literature review’, Energies, 14(19), p.6137.

Moonsamy, TA et al. (2022) ‘A new insight into integrated first and second-generation bioethanol production from sugarcane’, Industrial Crops and Products, 188, p.115675.

Neto, PAM (2021) ‘Why Brazil imports so much corn-based ethanol: The role of Brazilian and American ethanol blending mandates’, Renewable and Sustainable Energy Reviews, 152, p.111706.

Pavão, LV et al. (2023) ‘Flexible heat integration system in first-/second-generation ethanol production via screening pinch-based method and multiperiod model’, Energy, 271, p.127017.

Pinto, AS et al. (2021) ‘Techno-economic feasibility of biomass washing in 1G2G sugarcane biorefineries’, BioEnergy Research, 14, pp.1253-1264.

Rabelo, SC (2010) Avaliação e otimização de pré-tratamentos e hidrólise enzimática do bagaço de cana-de-açúcar para a produção de etanol de segunda geração. [Tese de Doutorado, instituição não informada].

Rodionova, MV et al. (2022) ‘A comprehensive review on lignocellulosic biomass biorefinery for sustainable biofuel production’, International Journal of Hydrogen Energy, 47(3), pp.1481-1498.

Silva Martins, LH et al. (2015) ‘Effects of the pretreatment method on high solids enzymatic hydrolysis and ethanol fermentation of the cellulosic fraction of sugarcane bagasse’, Bioresource Technology, 191, pp.312-321.

Sindhu, R et al. (2016) ‘Bioconversion of sugarcane crop residue for value added products–An overview’, Renewable Energy, 98, pp.203-215.

União da Indústria de Cana-de-Açúcar e Bioenergia - UNICA (2023). Disponível em: at: https://unica.com.br/noticias/colombia-se-aproxima-do-brasil-pelo-etanol (Acesso: 06 Outubro 2025).

Vandenberghe, LPS et al. (2022) ‘Beyond sugar and ethanol: The future of sugarcane biorefineries in Brazil’, Renewable and Sustainable Energy Reviews, 167, p.112721.

Vasconcelos, MH (2017) Desenvolvimento e análise econômica de modelos de biorrefinaria integrada 1G2G empregando pré-tratamento ácido diluído. [Tese de Doutorado, Universidade de São Paulo].

Vasconcelos, MH et al. (2020) ‘Techno-economic assessment of bioenergy and biofuel production in integrated sugarcane biorefinery: Identification of technological bottlenecks and economic feasibility of dilute acid pretreatment’, Energy, 199, p.117422.

Vieira, S et al. (2020) ‘Sustainability of sugarcane lignocellulosic biomass pretreatment for the production of bioethanol’, Bioresource Technology, 299, p.122635.

Published

11/29/2025

Issue

Section

Energias de Baixo Carbono

How to Cite

Pansiere Zavarise, J. (2025) “Technical-economic evaluation of the implementation of an integrated ethanol biorefinery: literature review”, Latin American Journal of Energy Research, 12(3), pp. 83–92. doi:10.21712/lajer.2025.v12.n3.p83-92.

Similar Articles

11-20 of 47

You may also start an advanced similarity search for this article.