PaO2/FiO2 RATIO, current volume, lactate and prognosis in sepsis

Abstract

Introduction: Sepsis comprises a set of inflammatory reactions that lead to organic dysfunction. Rapid sepsis identification and appropriate therapy are associated with better prognosis. The collection of laboratory tests, such as blood gas and arterial lactate, should be performed within 1 hour after diagnosis. Objective: Featuring patients diagnosed with sepsis, who were hospitalized in the Northern and Southern Intensive Care Units and in the Adult Emergency Unit of the General Hospital of Grajaú. Methods: Exploratory-descriptive research of quantitative, prospective nature. Data were collected in the electronic medical records of patients included in the Institutional Adult Sepsis Protocol, who were subjected to invasive mechanical ventilation. Results were subjected to descriptive statistics analysis. Results: Nineteen (19) patients were included in the current study, 79% of them were men. Factors such as age, comorbidities, vasoactive drug using and invasive procedures appear to be associated with worsened sepsis. Arterial lactate recorded median value of 29.40mmol/L for female patients and 27mmol/L, for male patients. The PaO2/FiO2 ratio recorded median value of 258mmHg for female patients and 185.5mmHg, for male patients; mean tidal volume was 6.50ml/Kg for female patients and 6.0ml/Kg, for male patients - 94.73% of patients assessed in the current study have died. Conclusion: Sepsis was more often observed in male patients with comorbidities. These patients used invasive devices such as invasive mechanical ventilation and central venous catheter. They recorded high arterial lactate values, slightly reduced PaO2/FiO2 ratio, long hospitalization time and invasive mechanical ventilation using, as well as high mortality rate.