Treatment of primary immune thrombocytopenia in adults: a literature review
DOI:
https://doi.org/10.47456/rbps.v26isupl_1.44404Keywords:
Immune thrombocytopenia, Corticosteroids, Splenectomy, RituximabAbstract
Introduction: Primary Immune Thrombocytopenia is an autoimmune disorder characterized by isolated thrombocytopenia and consequent hemorrhagic phenomen, whitch mechanism is related to platelet destruction by autoantibodies, as well as dysregulation of magakariopoiesis. The clinical presentation is characterized by thrombocytopenia <100,000/mm³ and the presence of varied mucocutaneous bleeding, requiring the exclusion of other causes of thrombocytopenia for diagnosis. Treatment aims to reduce bleeding risk by increasing platelet levels, through therapies that involve corticosteroids, immunosuppressants, thrombopoietin receptor agonist (ARTPO) and splenectomy. Objectives: Review and describe treatment in the setting of both newly diagnosed disease and persistent/chronic disease, bringing together international protocols and those published by the Brazilian Ministry of Health. Methods: Bibliographic review carried out in the Pubmed database, considering articles with the keyword “Immune Thrombocytopenia treatment in adults”. Conclusion: The management of primary immune thrombocytopenia in adults can be challenging, given the high rate of progression to the chronic form, requiring recurrent treatments in relapse scenarios and therapies with some degree of immunosuppression, impacting the patient’s morbidity and quality of life.
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