Clinical management of complications of sickle cell disease in the emergency room: literature review

Authors

  • Wilmar Barros Muniz Carréra
  • Síbia Soraya Marcondes
  • Marcos Daniel de Deus Santos

DOI:

https://doi.org/10.47456/rbps.v26isupl_1.44402

Keywords:

Sickle Cell Disease, Hemoglobinopathy, Emergency

Abstract

Introduction: Sickle Cell Disease (SCD) is a genetically determined disease where the amino acid glu­tamic acid is replaced by valine, in position 6 of the beta globin chain, resulting in anomalous hemo­globin. It is described by chronic hemolytic anemia, specific vaso-occlusive and progressive vascular lesions. In Brazil, it represents the most common monogenic hereditary disease and it is estimated that there are between 60,000 and 100,000 Brazilians with sickle cell anemia. Objectives: Review and de­scribe the initial management to be carried out by the clinical physician, still in the emergency depart­ment, of the main complications arising from the disease. Methods: Bibliographic review carried out in the Pubmed database, considering articles with the keyword “sickle cell disease emergency”. Results: SCD presents complications such as vaso-occlusive pain crises, acute chest syndrome, infections and others that must be quickly diagnosed in order to quickly start treatment with analgesics, antibiotics or simple or exchange blood transfusions, among others. specific treatments indicated according to each complication. When not diagnosed and treated quickly, they can be fatal. Conclusion: SCD is still a very prevalent pathology in the world with a high rate of morbidity and mortality, related to the compli­cations of the disease. Therefore, a quick and accurate diagnosis by healthcare professionals in urgency and emergency departments is extremely important to ensure quality care for patient.

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Published

2024-04-30

How to Cite

1.
Barros Muniz Carréra W, Soraya Marcondes S, de Deus Santos MD. Clinical management of complications of sickle cell disease in the emergency room: literature review. RBPS [Internet]. 2024 Apr. 30 [cited 2024 Nov. 25];26(supl_1):104-11. Available from: https://periodicos.ufes.br/rbps/article/view/44402

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Section

Artigos de Revisão