Fatores de risco associados ao abandono do tratamento de tuberculose no estado do Rio de Janeiro, Brasil, 2015-2019
DOI:
https://doi.org/10.47456/rbps.v23i2.34915Keywords:
Tuberculose, Aderência ao Medicamento, Adesão do Paciente, EpidemiologiaAbstract
Introduction: Abandonment of tuberculosis treatment is one of the main obstacles to control the disease in Brazil and in the world. In 2018, the state of Rio de Janeiro registered a 15.5% treatment abandonment rate in new cases, which is above the recommended by WHO. Objectives: Investigating factors associated with the abandonment of treatment according to sociodemographic and clinical-epidemiological characteristics of new tuberculosis cases in the state of Rio de Janeiro, Brazil. Methods: Data from the Health Notification Information System for the period 2015-2019 were used. The association of explanatory variables with treatment abandonment was explored through univariate and multivariate binary logistic regression models. Results: Out of the 14,831 individuals with tuberculosis included in the study, 1,852 abandoned treatment, representing 12.5% of the sample. Young males, with low schooling, of non-white color, smokers, and illicit drug users showed a predisposition to abandon treatment; the homeless population presented the highest chance of abandoning treatment. Conclusion: The study shows the importance of following these patient profiles to develop strategies that increase patient compliance to tuberculosis treatment.
Downloads
References
World Health Organization. Global Tuberculosis Report 2020. Geneva: World Health Organization; 2020.
Ministério da Saúde. Boletim Epidemiológico - Tuberculose 2021. Brasília: Ministério da Saúde; 2021.
Ministério da Saúde. Série Histórica Do Coeficiente de Incidência de Tuberculose. Brasil, Regiões e Unidades Federadas de Residência Por Ano de Diagnóstico (1990 a 2017) [Internet]. 2018 [cited on Jul 10, 2020]. Available at: http://portalarquivos2.saude.gov.br/images/pdf/2017/ novembro/22/taxa-incidencia-tuberculose-1990-2016- MAI-2017.pdf.
Ministério da Saúde. Brasil Livre Da Tuberculose - Plano Nacional Pelo Fim Da Tuberculose Como Problema de Saúde Pública. Brasília: Ministério da Saúde; 2017.
Ministério da Saúde. Manual de Recomendações Para o Controle Da Tuberculose No Brasil - 2a Edição Atualizada. Brasília: Ministério da Saúde; 2019.
Kulkarni P, Akarte S, Mankeshwar R, Bhawalkar J, Banerjee A, Kulkarni A. Non-Adherence of New Pulmonary Tuberculosis Patients to Anti-Tuberculosis Treatment. Ann Med Health Sci Res. 2013;3(1):74. https:// doi.org/10.1186/s13104-018-3789-4.
Silva P da F, Moura GS, Caldas A de JM. Fatores associados ao abandono do tratamento da tuberculose pulmonar no Maranhão, Brasil, no período de 2001 a 2010. Cad Saude Publica. 2014;30(8):1745-1754. https://doi. org/10.1590/0102-311X00124513.
Wurie FB, Cooper V, Horne R, Hayward AC. Determinants of non-adherence to treatment for tuberculosis in high-income and middle-income settings: A systematic review protocol. BMJ Open. 2018;8(1):e019287. http://dx.doi. org/10.1136/bmjopen-2017-019287.
Herrero MB, Ramos S, Arrossi S. Determinantes da não adesão ao tratamento da tuberculose na argentina: Barreiras relacionadas com o acesso ao tratamento. Rev Bras Epidemiol. 2015;18(2):287-298. https://doi. org/10.1590/1980-5497201500020001.
Chirinos NEC, Meirelles BHS. Fatores associados ao abandono do tratamento da tuberculose: Uma revisão integrativa. Texto e Context Enferm. 2011;20(3):599-606. https://doi.org/10.1590/S0104-07072011000300023.
R Core Team. R: A Language and Environment for Statistical Computing. 2020. https://www.r-project.org/.
Ministério da Saúde. RESOLUÇÃO No 510, DE 7 DE ABRIL DE 2016. Brasil: Ministério da Saúde [Internet]. 2016 [cited on Jul 10, 2020]. Available at: https://bvsms.saude.gov.br/bvs/saudelegis/cns/2016/ res0510_07_04_2016.html
Soares MLM, Amaral NAC do, Zacarias ACP, et al. Aspectos sociodemográficos e clínico-epidemiológicos do abandono do tratamento de tuberculose em Pernambuco, Brasil, 2001-2014. Epidemiol e Serviços Saúde. 2017;26(2):369-378. https://doi.org/10.5123/s1679- 49742017000200014.
Arruda SP. Fatores Associados ao Abandono do Tratamento da Tuberculose de Pacientes Residentes nas Comunidades da Rocinha e Manguinhos, Rio de Janeiro, Brasil [masters dissertation]. Rio de Janeiro: Univeridade Federal do Estado do Rio de Janeiro; 2016.
Oliveira GP. Abandono de tratamento da tuberculose no Município do Rio de Janeiro: construção de modelo sistêmico e análise de fatores associados a partir de bases de dados secundárias [doctoral thesis]. Rio de Janeiro: Univeridade Federal do Rio de Janeiro; 2017.
Harling G, Lima Neto AS, Sousa GS, Machado MMT, Castro MC. Determinants of tuberculosis transmission and treatment abandonment in Fortaleza, Brazil. BMC Public Health. 2017;17(1):508. https://doi.org/10.1186/ s12889-017-4435-0
Mota de Faria Gomes N, Cardoso da Mota Bastos M, Magliano Marins R, et al. Differences between Risk Factors Associated with Tuberculosis Treatment Abandonment and Mortality. Pulm Med. 2015;2015. https://doi. org/10.1155/2015/546106
Mendes A de M, Fensterseifer LM. Tuberculose: porque os pacientes abandonam o tratamento? Bol Pneumol Sanitária. 2004;12(1):25-36.
Viana PV de S, Redner P, Ramos JP. Fatores associados ao abandono e ao óbito de casos de tuberculose drogarresistente (TBDR) atendidos em um centro de referência no Rio de Janeiro, Brasil. Cad Saude Publica. 2018;34(5). https://doi.org/10.1590/0102-311x00048217.
Paixão LMM, Gontijo ED. Profile of notified tuberculosis cases and factors associated with treatment dropout. Rev Saude Publica. 2007;41(2):205-213. https:// doi.org/10.1590/S0034-89102007000200006.
Culqui DR, Grijalva CG, Del Rocío Reategui S, Cajo JM, Suárez LA. Predictive factors for noncompliance with tuberculosis treatment in an endemic region of Peru. Ver
Panam Salud Publica/Pan Am J Public Heal. 2005;18(1):14- 20. https://doi.org/10.1590/s1020-49892005000600003
Getahun H, Gunneberg C, Sculier D, Verster A, Ravigli¬one M. Tuberculosis and HIV in people who inject drugs: evidence for action for tuberculosis, HIV, prison and harm reduction services. Curr Opin HIV AIDS. 2012;7(4):345- 353. https://doi.org/10.1097/COH.0b013e328354bd44.
Júnior GMS, Santos, Diego Oliveira Gibaut M de AM, Bispo TCF. Tuberculose: Adesão ao Tratamento e os Fatores que Desencadeiam em Abandono. Rev Enferm Contemp. 2016;5(2):284-292.
Soares LN, Spagnolo LM de L, Tomberg JO, Zanatti CL de M, Cardozo-Gonzales RI. Relationship between multi¬morbidity and the outcome of the treatment for pulmo¬nary tuberculosis. Rev Gauch Enferm. 2020;41:e20190373. https://doi.org/10.1590/1983-1447.2020.20190373
Cabral Mendonça AM, Kritski AL, Poirot Land MG, Sant’Anna CC. Abandonment of treatment for latent tuber¬culosis infection and socioeconomic factors in children and adolescents: Rio de Janeiro, Brazil. PLoS One. 2016;11(5). https://doi.org/10.1371/journal.pone.0154843.
Gaspar RS, Nunes N, Nunes M, Rodrigues VP. Temporal analysis of reported cases of tuberculosis and of tuberculosis-HIV co-infection in Brazil between 2002 and 2012. J Bras Pneumol. 2016;42(6):416-422.https://doi. org/10.1590/s1806-37562016000000054.
Rodrigues ILA, Monteiro LL, Pacheco RHB, da Silva SÉD. Abandono do tratamento de tuberculose em co-infectados TB/HIV. Rev da Esc Enferm. 2010;44(2):383- 387. https://doi.org/10.1590/S0080-62342010000200020.
Silva CCAV, Andrade MS, Cardoso MD. Fatores asso¬ciados ao abandono do tratamento de tuberculose em in¬divíduos acompanhados em unidades de saúde de referência na cidade do Recife, Estado de Pernambuco, Brasil, entre 2005 e 2010. Epidemiol e Serviços Saúde. 2013;22(1):77-85. http://dx.doi.org/10.5123/S1679-49742013000100008.
De Abreu RG, Rolim LS, de Sousa AIA, de Oliveira MRF. Tuberculosis and diabetes: Association with socio¬demographic characteristics and diagnosis and treatment of tuberculosis. Brazil, 2007-2011. Rev Bras Epidemiol. 2020;23. https://doi.org/10.1590/1980-549720200009.
Ranzani OT, Carvalho CRR, Waldman EA, Rodrigues LC. The impact of being homeless on the unsuccessful outcome of treatment of pulmonary TB in São Paulo State, Brazil. BMC Med. 2016;14(1):41. https://doi. org/10.1186/s12916-016-0584-8.
Downloads
Published
Issue
Section
License
Copyright (c) 2021 Revista Brasileira de Pesquisa em Saúde/Brazilian Journal of Health Research
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors and reviewers must disclose any financial, professional, or personal conflicts of interest that could influence the results or interpretations of the work. This information will be treated confidentially and disclosed only as necessary to ensure transparency and impartiality in the publication process.
Copyright
RBPS adheres to the CC-BY-NC 4.0 license, meaning authors retain copyright of their work submitted to the journal.
- Originality Declaration: Authors must declare that their submission is original, has not been previously published, and is not under review elsewhere.
- Publication Rights: Upon submission, authors grant RBPS the exclusive right of first publication, subject to peer review.
- Additional Agreements: Authors may enter into non-exclusive agreements for the distribution of the RBPS-published version (e.g., in institutional repositories or as book chapters), provided the original authorship and publication by RBPS are acknowledged.
Authors are encouraged to share their work online (e.g., institutional repositories or personal websites) after initial publication in RBPS, with appropriate citation of authorship and original publication.
Under the CC-BY-NC 4.0 license, readers have the rights to:
- Share: Copy and redistribute the material in any medium or format.
- Adapt: Remix, transform, and build upon the material.
These rights cannot be revoked, provided the following terms are met:
- Attribution: Proper credit must be given, a link to the license provided, and any changes clearly indicated.
- Non-Commercial: The material cannot be used for commercial purposes.
- No Additional Restrictions: No legal or technological measures may be applied to restrict others from doing anything the license permits.
