HIV/AIDS infection: endoscopic characteristics of the most common esophageal lesions and propaedeutics
DOI:
https://doi.org/10.47456/rbps.v26isupl_1.44401Keywords:
Esophagus, HIV infection, AIDS, Endoscopic findingsAbstract
Introduction: The gastrointestinal tract is one of the main sites of disease in human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS). In this article we will address esophageal disease associated with HIV, with emphasis on its endoscopic and histopathological findings. Objectives: The objective of this review is to describe the characteristics of the main endoscopic findings of the esophagus associated with HIV/AIDS, with emphasis on diagnosis and management in the face of macroscopic findings. Methods: Review of the medical literature of articles selected from PubMed. Results: The most common esophageal lesions associated with HIV/AIDS are candida esophagitis, Cytomegalovirus (CMV) infections, herpes simplex virus (HSV) and idiopathic ulceration. The most common clinical condition is the development of acute symptoms, such as dysphagia and odynophagia, leading to a reduction in food intake, worsening the clinical condition of immunosuppressed patients due to the worsening of nutritional status. The best diagnostic test is upper digestive endoscopy, which allows the evaluation of the esophageal mucosa and collection of biopsies for histopathology. Conclusion: Clinical suspicion of esophageal lesions, during upper digestive endoscopy in patients without a diagnosis of HIV infection and careful observation of esophageal lesions, with correct acquisition of material for study in patients known to be infected or not, can modify treatment and the patient with HIV/AIDS’s prognosis.
Downloads
References
Bhaijee F, Subramony C, Tang SJ, Pepper DJ. Human Immuno¬deficiency Virus-Associated Gastrointestinal Disease: Com¬mon Endoscopic Biopsy Diagnoses. Pathol Res Int. 2011 Apr 26;2011:1-8. doi: 10.4061/2011/247923.
Chong VH, Lim CC. Human immunodeficiency virus and endoscopy: Experience of a general hospital in Singapore. J Gas¬troenterol Hepatol. 2005 Mar 15;20(5):722-6.
Peruzzi PE. Esofagites Infecciosa. In: Averbach M, editor. Atlas de Endoscopia Digestiva da SOBED. 2nd ed. Rio de Janeiro: Thieme Revinter; 2020. p. 81-88.
Mohamed AA, Lu X, Mounmin FA. Diagnosis and Treatment of Esophageal Candidiasis: Current Updates. Can J Gastroenterol Hepatol. 2019 Oct 20;2019:1-6. doi: 10.1155/2019/3587186.
Wilcox CM. Consequências Gastrointestinais da infecção por Vírus da Imunodeficiência Adquirida. In: Feldman M, et al., edi¬tors. Sleisenger and Fordtran’s Gastrointestinal and Liver Dis¬ease. 9th ed. Vol. 1. Rio de Janeiro: Elsevier; 2014. p. 533-544.
Fitting D. Kodsi classification of Candida esophagitis. Endos¬copy Campus [Internet]. Available from: https://www.endosco¬py-campus.com/en/classifications/kodsi-classification-of-can¬dida-esophagitis/ [accessed 2023 Sep 30].
Jung KH, Choi J, Gong EJ, Lee JH, Choi KD, Song HJ, et al. Can endoscopists differentiate cytomegalovirus esophagitis from herpes simplex virus esophagitis based on gross endoscopic findings? Medicine (Baltimore). 2019 Jun;98(23):e15845. doi: 10.1097/MD.0000000000015845.
Iwamuro M, Kondo E, Tanaka T, Hagiya H, Kawano S, Kawahara Y, et al. Endoscopic Manifestations and Clinical Characteristics of Cytomegalovirus Infection in the Upper Gastrointestinal Tract. Acta Med Okayama. 2017 Apr 1;71(2):97-104.
Nkuize M, De Wit S, Muls V, Arvanitakis M, Buset M. Upper gastrointestinal endoscopic findings in the era of highly active antiretroviral therapy. HIV Med. 2010 Jul 1;11(6):412-7.
Généreau T, Rozenberg F, Bouchaud O, Marche C, Lortholary O. Herpes esophagitis: a comprehensive review. Clin Microbiol Infect. 1997 Aug;3(4):397-407.
Zaidi SA, Cervia JS. Diagnosis and Management of Infectious Esophagitis Associated with Human Immunodeficiency Virus Infection. J Int Assoc Physicians AIDS Care. 2002 Apr;1(2):53-62.
Kodsi BE, et al. Candida esophagitis: a prospective study of 27 cases. Gastroenterology. 1976 Nov;71(5):715-9. PMID: 964563.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Brazilian Journal of Health Research

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors and reviewers must disclose any financial, professional, or personal conflicts of interest that could influence the results or interpretations of the work. This information will be treated confidentially and disclosed only as necessary to ensure transparency and impartiality in the publication process.
Copyright
RBPS adheres to the CC-BY-NC 4.0 license, meaning authors retain copyright of their work submitted to the journal.
- Originality Declaration: Authors must declare that their submission is original, has not been previously published, and is not under review elsewhere.
- Publication Rights: Upon submission, authors grant RBPS the exclusive right of first publication, subject to peer review.
- Additional Agreements: Authors may enter into non-exclusive agreements for the distribution of the RBPS-published version (e.g., in institutional repositories or as book chapters), provided the original authorship and publication by RBPS are acknowledged.
Authors are encouraged to share their work online (e.g., institutional repositories or personal websites) after initial publication in RBPS, with appropriate citation of authorship and original publication.
Under the CC-BY-NC 4.0 license, readers have the rights to:
- Share: Copy and redistribute the material in any medium or format.
- Adapt: Remix, transform, and build upon the material.
These rights cannot be revoked, provided the following terms are met:
- Attribution: Proper credit must be given, a link to the license provided, and any changes clearly indicated.
- Non-Commercial: The material cannot be used for commercial purposes.
- No Additional Restrictions: No legal or technological measures may be applied to restrict others from doing anything the license permits.