Clinical and epidemiological profile of tuberculosis patients diagnosed in a university hospital
DOI:
https://doi.org/10.21722/rbps.v22i1.27439Keywords:
Tuberculosis, Epidemiology, Public Health, DiagnosticsAbstract
Introduction: Tuberculosis is an infectious disease that represents a serious public health issue, since it affects approximately one third of the world’s population. Objective: Analyzing the clinical and epidemiological profile of patients diagnosed with tuberculosis in a university hospital. Methods: Cross-sectional, retrospective, quantitative study comprising 118 patients diagnosed with tuberculosis from January 2013 to December 2017. Data collection was based on a form encompassing sociodemographic and epidemiological variables, which was elaborated based on the investigation form used by the Information System for Notifiable Diseases. Data were analyzed in SPSS® software. The research was approved by the Research Ethics Committee of the University Hospital of Federal University of Piauí. Results: There was prevalence of tuberculosis among male patients who had low schooling, brown skin color and who came from other counties in Piauí State. Based on the bivariate analysis, elderly patients with positive sputum smear microscopy, suspected x-ray, positive culture and detectable rapid molecular test were more prone to be diagnosed with the pulmonary form of the disease. Conclusion: There was high percentage of patients with pulmonary tuberculosis diagnosed in the hospital service, although both the diagnosis and treatment are available in the primary care. In addition, it was evident that social determinants play a key role in the incidence of tuberculosis cases among lower-income populations.
Downloads
Download data is not yet available.
References
1. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasil Livre da Tuberculose: Plano Nacional pelo Fim da Tuberculose como Problema de Saúde Pública. Guia de vigilância em saúde. Brasília: Ministério da Saúde; 2017. [cited em 2018 jul 26]. Availabe from: http://bvsms.saude.gov.br/bvs/publicacoes/brasil_livre_tuberculose_plano_nacional.pdf
2. World Health Organization. Bending the curve - ending TB: Annual report 2017 [Internet]. Geneva: World Health Organization; 2017 [cited 2018 Mar 8]. 72 p. Available from: https://apps.who.int/iris/handle/10665/254762.
3. World Health Organization. Global Tuberculosis Report 2013. [Internet] 2013. [cited 2018 Set 20]. Available from:
http://apps.who.int/iris/bitstream/handle/10665/91355/9789241564656_eng.pdf?sequence=1
4. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Boletim Epidemiológico. Implantação do plano nacional pelo fim da tuberculose como problema de saúde pública no Brasil: primeiros passos rumo ao alcance das metas. Brasília: Ministério da Saúde; 2018. [acesso em 26 jul 2018];49(11):1-18 Availabe from: http://portalarquivos2.saude.gov.br/images/pdf/2018/marco/26/2018-009.pdf
5. Chaves J, Tomilin BA, Brun D, Fuhr LG, Ourique F, Pilletti K, et al. Perfil dos pacientes com tuberculose que foram atendidos em uma unidade de referência do município de Santa Cruz do Sul – RS no período de 2009 a 2013. J Health Biol Sci [Internet]. 2017 [cited 2018 Jul 26];5(1):31-6. Avaliable from: http://dx.doi.org/10.12662/2317-3076jhbs.v5i1.902.p31-36.2017
6. Santos MCS, Andrade RPS, Macedo SM, Andrade ASS, Villa TCS, Pinto ESG. Organization of primary healthcare services for tuberculosis diagnosis and treatment. Cogitare Enferm. [Internet] 2017. [cited 2018 Jul 26]; (22)2: e48151. DOI: http://dx.doi.org/10.5380/ce.v22i2.48151
7. Vieira AN, Lima DWC, Souza JB, Leite ACQB, Medeiros CPP, Fonseca HÁ. Acesso ao diagnóstico da tuberculose na atenção primária à saúde. Rev APS. [Internet] 2017 Jul Sep. [cited 2018 jun 26];20(3):323-30. Available from: https://aps.ufjf.emnuvens.com.br/aps/article/view/2432
8. Andrade HS, Amaral JL, Fonseca DF, Oliveira VC, Gontijos TL, Guimarães EAA. Clinical epidemiological features of new tuberculosis cases. J Nurs UFPE on line [Internet]. 2016 July [cited 2018 Jul 26];10(7):2528-36. Available from: https://periodicos.ufpe.br/revistas/revistaenfermagem/article/view/11311
9. Chaves EC, Carneiro ICRS, Santos MIPO, Sarges NA, Neves EOS. Aspectos epidemiológicos, clínicos e evolutivos da tuberculose em idosos de um hospital universitário em Belém, Pará. Rev Bras Geriatr Gerontol. [Internet] 2017 [cited 2018 Jul 26];20(1):47-58. Available from: http://dx.doi.org/10.1590/1981-22562017020.160069
10. Maior ML, Guerra RL, Cezar MC, Golub JE, Conde MB. Time from symptom onset to the initiation of treatment of pulmonary tuberculosis in a city with a high incidence of the disease. J Bras Pneumol. [Internet] 2012 [cited 2018 Jul 26];38(2):202-9. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132012000200009
11. Pereira JC, Silva MR, Costa RR, Guimarães MDC, Leite ICG. Profile and follow-up of patients with tuberculosis in a priority city in Brazil. Rev Saúde Pública. [Internet] 2015. [cited 2018 Jul 26];49(6):1-12. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102015000100205
12. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Boletim Epidemiológico. Secretaria de Vigilância em Saúde. Detectar, tratar e curar: desafios e estratégias brasileiras frente à tuberculose. Brasília: Ministério da Saúde; 2015 [cited em 2018 jul 26];46(9):1-19. Availabe from: http://portalarquivos2.saude.gov.br/images/pdf/2015/marco/25/Boletim-tuberculose-2015.pdf
13. Barros PG, Pinto ML, Silva TC, Silva EL, Figueiredo TMRM de. Perfil Epidemiológico dos casos de Tuberculose Extrapulmonar em um município do estado da Paraíba, 2001- 2010. Cad. Saúde Colet [Internet]. 2014 [cited 2018 Jul 26];22(4):343-50. DOI: <http://dx.doi.org/10.1590/1414-462X201400040007>.
14. Pereira AGL, Medronho RA, Escosteguy CC, Valencia LIO, Magalhães MAFM. Distribuição espacial e contexto socioeconômico da tuberculose, Rio de Janeiro, Brasil. Rev Saúde Pública. [Internet]. 2015. [cited 2018 Oct 05];49(48):1-9. DOI: < http://dx.doi.org/10.1590/S0034-8910.2015049005470>
15. Reis SP, Harter J, Lima LM, Vieira DA, Palha PF, Gonzales RIC. Aspectos geográficos e organizacionais dos serviços de atenção primária à saúde na detecção de casos de tuberculose em Pelotas, Rio Grande do Sul, 2012. Epidemiol Serv Saude. [Internet] 2017 Jan Mar. [cited 2018 Jul 26];26(1):141-8. DOI:< http://dx.doi.org/10.5123/s1679-49742017000100015>
16. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Guia de vigilância em saúde. Brasília: Ministério da saúde; 2016. Availabe from: http://bvsms.saude.gov.br/bvs/publicacoes/guia_vigilancia_saude_1ed_atual.pdf
17. Freitas WMTM, Santos CC, Silva MM, Rocha GA. Perfil clínico-epidemiológico de pacientes portadores de tuberculose atendidos em uma unidade municipal de saúde de Belém, Estado do Pará, Brasil. Rev Pan-Amaz Saude [Internet] 2016 [cited 2018 Jul 26];7(2):45-50. Available from: http://scielo.iec.gov.br/scielo.php?script=sci_arttext&pid=S2176-62232016000200045
18. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância Epidemiológica. Manual de Recomendações para o Controle da Tuberculose no Brasil. Brasília (DF): Ministério da Saúde; 2011.
19. UNITED NATIONS PROGRA MME on HIV/AIDS (UNAIDS).The Gap Report. 2014. [acesso em: 15 out 2017]. Available from: http://files.unaids.org/en/media/unaids/contentassets/documents/unaidspublication/2014/UNAIDS_Gap_report_en.pdf
20. Trinh QM, Nguyen HL, Nguyen VN, Nguyen TV, Sintchenko V, Marais BJ. Tuberculosis and HIV co-infection-focus on the Asia-Pacific region. Int J Infect Dis. [Internet]. 2015 Mar [cited 2018 jul 26 ];32:170-8. Available from: https://doi.org/10.1016/j.ijid.2014.11.023
21. Molina PE, Happel KI, Zhang P,Kolls JK,Nelson S. Focus on: alcohol and the immune system. Alcohol Res Health. 2010;33(1-2):97-108. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/23579940
22. Jabukowiak WM, Bogorodskaya EM, Borisov SE, Danilova ID, Kourbatova EV. Risk factors associated with default among new pulmonar TB patients and social support in six Russian regions. Int J Tuberc Lund Dis. 2007;11(1): 46-53. Available from: https://www.ncbi.nlm.nih.gov/pubmed/17217129
23. Workneh MH, Bejune GA, Wimer SA. Prevalence and associated factors of tuberculosis an diabetes mellitus comorbidity: a systematic review. PLoS One 2017; 12(4):e0175925. Available from: http://doi.org/10.1371/journal.pone.0175925
24. Maynard SL, Larke N, Peters JA, Lawn SD.Diagnostic accuracy of the Xpert MTB/RIF assay for extrapulmonary and pulmonary tuberculosis when testing non-respiratory samples: a systematic review. BMC Infect Dis. [Internet].2014 Dec [cited 2018 Jul 26];14(709):1-15. Available from: https://europepmc.org/abstract/med/25599808
2. World Health Organization. Bending the curve - ending TB: Annual report 2017 [Internet]. Geneva: World Health Organization; 2017 [cited 2018 Mar 8]. 72 p. Available from: https://apps.who.int/iris/handle/10665/254762.
3. World Health Organization. Global Tuberculosis Report 2013. [Internet] 2013. [cited 2018 Set 20]. Available from:
http://apps.who.int/iris/bitstream/handle/10665/91355/9789241564656_eng.pdf?sequence=1
4. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Boletim Epidemiológico. Implantação do plano nacional pelo fim da tuberculose como problema de saúde pública no Brasil: primeiros passos rumo ao alcance das metas. Brasília: Ministério da Saúde; 2018. [acesso em 26 jul 2018];49(11):1-18 Availabe from: http://portalarquivos2.saude.gov.br/images/pdf/2018/marco/26/2018-009.pdf
5. Chaves J, Tomilin BA, Brun D, Fuhr LG, Ourique F, Pilletti K, et al. Perfil dos pacientes com tuberculose que foram atendidos em uma unidade de referência do município de Santa Cruz do Sul – RS no período de 2009 a 2013. J Health Biol Sci [Internet]. 2017 [cited 2018 Jul 26];5(1):31-6. Avaliable from: http://dx.doi.org/10.12662/2317-3076jhbs.v5i1.902.p31-36.2017
6. Santos MCS, Andrade RPS, Macedo SM, Andrade ASS, Villa TCS, Pinto ESG. Organization of primary healthcare services for tuberculosis diagnosis and treatment. Cogitare Enferm. [Internet] 2017. [cited 2018 Jul 26]; (22)2: e48151. DOI: http://dx.doi.org/10.5380/ce.v22i2.48151
7. Vieira AN, Lima DWC, Souza JB, Leite ACQB, Medeiros CPP, Fonseca HÁ. Acesso ao diagnóstico da tuberculose na atenção primária à saúde. Rev APS. [Internet] 2017 Jul Sep. [cited 2018 jun 26];20(3):323-30. Available from: https://aps.ufjf.emnuvens.com.br/aps/article/view/2432
8. Andrade HS, Amaral JL, Fonseca DF, Oliveira VC, Gontijos TL, Guimarães EAA. Clinical epidemiological features of new tuberculosis cases. J Nurs UFPE on line [Internet]. 2016 July [cited 2018 Jul 26];10(7):2528-36. Available from: https://periodicos.ufpe.br/revistas/revistaenfermagem/article/view/11311
9. Chaves EC, Carneiro ICRS, Santos MIPO, Sarges NA, Neves EOS. Aspectos epidemiológicos, clínicos e evolutivos da tuberculose em idosos de um hospital universitário em Belém, Pará. Rev Bras Geriatr Gerontol. [Internet] 2017 [cited 2018 Jul 26];20(1):47-58. Available from: http://dx.doi.org/10.1590/1981-22562017020.160069
10. Maior ML, Guerra RL, Cezar MC, Golub JE, Conde MB. Time from symptom onset to the initiation of treatment of pulmonary tuberculosis in a city with a high incidence of the disease. J Bras Pneumol. [Internet] 2012 [cited 2018 Jul 26];38(2):202-9. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132012000200009
11. Pereira JC, Silva MR, Costa RR, Guimarães MDC, Leite ICG. Profile and follow-up of patients with tuberculosis in a priority city in Brazil. Rev Saúde Pública. [Internet] 2015. [cited 2018 Jul 26];49(6):1-12. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102015000100205
12. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Boletim Epidemiológico. Secretaria de Vigilância em Saúde. Detectar, tratar e curar: desafios e estratégias brasileiras frente à tuberculose. Brasília: Ministério da Saúde; 2015 [cited em 2018 jul 26];46(9):1-19. Availabe from: http://portalarquivos2.saude.gov.br/images/pdf/2015/marco/25/Boletim-tuberculose-2015.pdf
13. Barros PG, Pinto ML, Silva TC, Silva EL, Figueiredo TMRM de. Perfil Epidemiológico dos casos de Tuberculose Extrapulmonar em um município do estado da Paraíba, 2001- 2010. Cad. Saúde Colet [Internet]. 2014 [cited 2018 Jul 26];22(4):343-50. DOI: <http://dx.doi.org/10.1590/1414-462X201400040007>.
14. Pereira AGL, Medronho RA, Escosteguy CC, Valencia LIO, Magalhães MAFM. Distribuição espacial e contexto socioeconômico da tuberculose, Rio de Janeiro, Brasil. Rev Saúde Pública. [Internet]. 2015. [cited 2018 Oct 05];49(48):1-9. DOI: < http://dx.doi.org/10.1590/S0034-8910.2015049005470>
15. Reis SP, Harter J, Lima LM, Vieira DA, Palha PF, Gonzales RIC. Aspectos geográficos e organizacionais dos serviços de atenção primária à saúde na detecção de casos de tuberculose em Pelotas, Rio Grande do Sul, 2012. Epidemiol Serv Saude. [Internet] 2017 Jan Mar. [cited 2018 Jul 26];26(1):141-8. DOI:< http://dx.doi.org/10.5123/s1679-49742017000100015>
16. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Guia de vigilância em saúde. Brasília: Ministério da saúde; 2016. Availabe from: http://bvsms.saude.gov.br/bvs/publicacoes/guia_vigilancia_saude_1ed_atual.pdf
17. Freitas WMTM, Santos CC, Silva MM, Rocha GA. Perfil clínico-epidemiológico de pacientes portadores de tuberculose atendidos em uma unidade municipal de saúde de Belém, Estado do Pará, Brasil. Rev Pan-Amaz Saude [Internet] 2016 [cited 2018 Jul 26];7(2):45-50. Available from: http://scielo.iec.gov.br/scielo.php?script=sci_arttext&pid=S2176-62232016000200045
18. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância Epidemiológica. Manual de Recomendações para o Controle da Tuberculose no Brasil. Brasília (DF): Ministério da Saúde; 2011.
19. UNITED NATIONS PROGRA MME on HIV/AIDS (UNAIDS).The Gap Report. 2014. [acesso em: 15 out 2017]. Available from: http://files.unaids.org/en/media/unaids/contentassets/documents/unaidspublication/2014/UNAIDS_Gap_report_en.pdf
20. Trinh QM, Nguyen HL, Nguyen VN, Nguyen TV, Sintchenko V, Marais BJ. Tuberculosis and HIV co-infection-focus on the Asia-Pacific region. Int J Infect Dis. [Internet]. 2015 Mar [cited 2018 jul 26 ];32:170-8. Available from: https://doi.org/10.1016/j.ijid.2014.11.023
21. Molina PE, Happel KI, Zhang P,Kolls JK,Nelson S. Focus on: alcohol and the immune system. Alcohol Res Health. 2010;33(1-2):97-108. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/23579940
22. Jabukowiak WM, Bogorodskaya EM, Borisov SE, Danilova ID, Kourbatova EV. Risk factors associated with default among new pulmonar TB patients and social support in six Russian regions. Int J Tuberc Lund Dis. 2007;11(1): 46-53. Available from: https://www.ncbi.nlm.nih.gov/pubmed/17217129
23. Workneh MH, Bejune GA, Wimer SA. Prevalence and associated factors of tuberculosis an diabetes mellitus comorbidity: a systematic review. PLoS One 2017; 12(4):e0175925. Available from: http://doi.org/10.1371/journal.pone.0175925
24. Maynard SL, Larke N, Peters JA, Lawn SD.Diagnostic accuracy of the Xpert MTB/RIF assay for extrapulmonary and pulmonary tuberculosis when testing non-respiratory samples: a systematic review. BMC Infect Dis. [Internet].2014 Dec [cited 2018 Jul 26];14(709):1-15. Available from: https://europepmc.org/abstract/med/25599808
Additional Files
Published
2020-12-23
How to Cite
1.
Furtado Érida ZL, Rodrigues LMC, Monteiro AS, Oliveira AKN, Martins EM. Clinical and epidemiological profile of tuberculosis patients diagnosed in a university hospital. RBPS [Internet]. 2020 Dec. 23 [cited 2024 Jul. 17];22(1):50-9. Available from: https://periodicos.ufes.br/rbps/article/view/27439
Issue
Section
Artigos originais
License
Copyright (c) 2020 Revista Brasileira de Pesquisa em Saúde/Brazilian Journal of Health Research
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
