Efficacy of using corticosteroids as adjunctive therapy in septic shock

Authors

DOI:

https://doi.org/10.47456/bjpe.v8i1.37280

Keywords:

Efficiency, Corticosteroids, Therapy, Septic shock

Abstract

Context: Septic shock is a state of acute circulatory failure combined with an infectious focus or with a predominance of an endotoxic component. Corticosteroid therapy has been used with the main focus on hypoperfusion. Corticosteroids are a class of drugs synthesized on the basis of endocrine steroid hormones, which are produced and secreted by the cortex of the adrenal glands. However, the efficacy and safety of corticosteroid therapy in septic shock remains uncertain, as there are both reports of clinical improvement and serious adverse effects, such as superinfection and metabolic and neuromuscular effects. Objective: Given the above, the present study aims to evaluate the effectiveness of adjuvant therapy with corticosteroids in patients with septic shock in order to look for scientific evidence showing benefits of this treatment, as well as to establish, if positive, the management of according to the evidence, of corticosteroids in this pathology. Method: It is characterized as an Integrative Review, in which the articles were selected on the Virtual Health Library platform, in which 460 articles were identified, but after applying the filters and selection criteria, 39 were selected among them. Results: The country that was the target of studies on such behavior was the United States. These studies were carried out more frequently in 2017, 2018 and 2019. After analyzing the data, it was suggested that this therapy was related to a faster reversal of shock and a reduction in the days of vasopressor use, in addition to decreasing the length of stay in the ICU. However, there are risks of adverse effects. Conclusion: Therefore, it was concluded that patients who are candidates for this treatment are those with greater severity and/or who do not respond primarily to resuscitation with fluids and vasoactive drugs. Furthermore, the use of these medications must be individualized, considering.

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Author Biographies

Wellington Felipe Leite, Faculdades Integradas de Patos, FIP, Brasil

Graduating in Medicine at the University Center of Patos - UNIFIP. Vice-President and effective member of the Academic League of Surgical Clinic of the Centro Universitário de Patos - LACC-UNIFIP. Vice-President and effective member of the Academic League of Orthopedics and Traumatology of Faculdades Integradas de Patos - LAOT-FIP. Member of the Academic League of Family and Community Medicine of the Centro Universitário de Patos (LAMFAC-UNIFIP). Member of the research and extension project A-COR-DAR. Member of the International Federation of Medical Students Associations - IFMSA. (Text provided by the author)

Osman Batista de Medeiros Filho, Centro Universitário de Patos - UNIFIP

Graduated in Medicine from the Federal University of Paraíba (2012) and Residency in Internal Medicine at the Hospital das Clínicas of the Federal University of Pernambuco (2016). He works as a clinician and coordinator of the UFCG Health Care Center and as a clinician at the Alcides Carneiro University Hospital (HUAC) by Ebserh. He also works as Supervisor of the Mais Médicos Program at UFCG, performs the functions of Coordinator and preceptor of the Internal Medicine Internship at UNIFIP, professor of Gastroenterology at UNIFIP and preceptor of the Internal Medicine Residency at SMS Patos-PB. (Text provided by the author)

Milena Nunes Alves de Sousa, Centro Universitário de Patos - UNIFIP

Paraibana, daughter of Conceição, hinterland of Paraíba. Tourismologist from the Faculty of Applied Social Sciences (2004), Administrator from the State University of Paraíba (2007), Nurse from the Faculty of Campina Grande (2008), Master in Health Sciences from the Cruzeiro do Sul University (2009), Doctor in Health Promotion from the University of Franca (2014), Post-Doctorate in Health Promotion from the University of Franca (2016) and Post-Doctorate in Agroindustrial Systems from the Federal University of Campina Grande (2018). She is currently a professor at the Centro Universitário de Patos (UNIFIP), on a full-time basis. He has experience in the areas of Administration and Health, working mainly on the following topics: health promotion, environment and work, health and environment, aging and health, quality of life, health management and planning. She is currently Dean of Research, Extension and Graduate Studies at UNIFIP, Coordinator of the Investigative Practices in Health Axis and of the Course Completion Work of the Medicine Course at UNIFIP. She is a researcher in the research group: Seniors: behavior, gender and lifestyle. Orcid: 0000-0001-8327-9147. (Text provided by the author)

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Published

2022-02-22

How to Cite

Leite, W. F., Medeiros Filho, O. B. de, & Sousa, M. N. A. de. (2022). Efficacy of using corticosteroids as adjunctive therapy in septic shock. Brazilian Journal of Production Engineering, 8(1), 92–106. https://doi.org/10.47456/bjpe.v8i1.37280

Issue

Vol. 8 No. 1 (2022): Número Regular (Janeiro - Março)

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TECHNOLOGY AND INNOVATION IN HEALTH

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