Disseminated juvenile paracoccidoidomycosis evolving with portal hypertension: a case report

Taciana  de Souza Bayão; Giovanna Barille; Lucas Rodrigues Diniz; Cláudia Biasutti; Aloísio Falqueto

doi:10.47456/rbps.v26isupl_1.44396

Autores

Taciana de Souza Bayão
Giovanna Barille
Lucas Rodrigues Diniz
Cláudia Biasutti
Aloísio Falqueto

DOI:

https://doi.org/10.47456/rbps.v26isupl_1.44396

Palavras-chave:

Paracoccidioidomycosis, Portal hypertension, Paracoccidioides

Resumo

Introduction: Juvenile paracoccidioidomycosis (PCM), a disease caused by fungi of the genus Paracoccidioides, requires high clinical suspicion, as a range of differential diagnoses are possible. Case report: This report describes a patient diagnosed with juvenile PCM who, due to low adherence to treatment, developed a more extensive fungal invasion within eight years, causing portal hypertension due to portal vein thrombosis. This is a rare and serious manifestation. Conclusion: Only six similar reports were identified in the medical literature, through a search in the databases of the Pubmed and Scielo platforms.

Downloads

Não há dados estatísticos.

Referências

Peçanha PM, Peçanha-Pietrobom PM, Grão-Velloso TR, Rosa Júnior M, Falqueto A, Gonçalves SS. Paracoccidioidomycosis: What We Know and What Is New in Epidemiology, Diagno¬sis, and Treatment. J Fungi (Basel). 2022 Oct 18;8(10):1098. doi: 10.3390/jof8101098.

Shikanai-Yasuda MA, Mendes RP, Colombo AL, Queiroz-Telles F, Kono ASG, Paniago AMM, et al. Brazilian guidelines for the clinical management of paracoccidioidomycosis. Rev Soc Bras Med Trop. 2017 Sep-Oct;50(5):715-740. doi: 10.1590/0037-8682- 0230-2017.

Peçanha PM, Batista Ferreira ME, Massaroni Peçanha MA, Schmidt EB, Lamas de Araújo M, Zanotti RL, et al. Paracoccidi¬oidomycosis: Epidemiological and Clinical Aspects in 546 Cases Studied in the State of Espírito Santo, Brazil. Am J Trop Med Hyg. 2017 Sep;97(3):836-844. doi: 10.4269/ajtmh.16-0790.

Macedo PM, Almeida-Paes R, Freitas DFS, Brito-Santos F, Figue¬iredo-Carvalho MHG, Soares JCA, et al. Hepatic Disease with Portal Hypertension and Acute Juvenile Paracoccidioidomyco¬sis: A Report of Two Cases and Literature Review. Mycopathol. 2017 Oct;182(9-10):915-919. doi:10.1007/s11046-017-0152-6.

Marchiotti MC, Cabral JN, Zangirolami JW, Bressa, JAN. Paracoccidioidomicose subaguda septicêmica levando a infarto esplênico e trombose de veia porta no indivíduo imunocompe¬tente: a propósito de um caso. Braz J Infect Dis. 2021 25(S1), 101443. doi:10.1016/j.bjid.2020.101443

Stringuini FA, Naback PO, Araújo LF, Lima RB, Martins CJ. Severe paracoccidioidomycosis, with a fatal outcome and inci¬dence related to an environmental event. Br J Dermatol. 2023 98(1), 133-137. doi:10.1016/j.abd.2021.12.006

Rocha FL, Araújo TD. Acute paracoccidioidomycosis in a 40-year-old man: a case report and literature review. Myco¬pathol. 2017 Dec;182(11-12):1095-1099. doi: 10.1007/s11046-017- 0196-7.

Bermudes FT, Pareja HBJ, Sannino CP, Dias LVP, Saka¬moto MNG, Saab J, et al. Paracoccidioidomycosis causing Cholestatic Syndrome: a case report. Braz. J. Hea. Rev. 2022 Oct.13;5(5):20561-73. doi:10.34119/bjhrv5n5-223.

Filho FB, Sgarbi I, Domingos SFS, Sampaio RC, Queiroz RM, Fonseca SNS, Hay RJ, Towersey L. Acute paracoccidioidomy¬cosis with duodenal and cutaneous involvement and obstruc¬tive jaundice. Med Mycol Case Rep. 2018 Jan 12;20:21-25. doi: 10.1016/j.mmcr.2018.01.005.

Cazzo E, Ferrer JA, Chaim EA. Obstructive jaundice second¬ary to paracoccidioidomycosis. Trop Gastroenterol. 2015 Jan- Mar;36(1):46-7. doi: 10.7869/tg.244.

Savarese LG, Monsignore LM, Hernandes MA, Martinez R, Nogueira-Barbosa MH. Magnetic resonance imaging find¬ings of paracoccidioidomycosis in the musculoskeletal system. Trop Med Int Health. 2015 Oct;20(10):1346-54. doi: 10.1111/ tmi.12552.

Rodrigues FB, Machado AA, Martinez R. Paracoccidioidomyco¬sis epidemiological features of a 1,000- cases series from a hype¬rendemic area on the Southeast of Brazil. Am J Trop Med Hyg. 2011;85(3):546–50. doi:10.4269/ajtmh.2011.11-0084.