Análise clínica e epidemiológica da infecção por criptococose em pacientes do hospital de referência em doenças tropicais de Teresina, Brasil

Danilo Rafael da Silva Fontinele; Rafael dos Santos Nunes; Luiz Henrique Carvalho Silva; Liline Maria Soares Martins; Bodo Wanke

doi:10.47456/rbps.v24i2.36612

Autores

Danilo Rafael da Silva Fontinele
Rafael dos Santos Nunes UESPI - UNIVERSIDADE ESTADUAL DO PIAUÍ
Luiz Henrique Carvalho Silva
Liline Maria Soares Martins
Bodo Wanke

DOI:

https://doi.org/10.47456/rbps.v24i2.36612

Palavras-chave:

HIV, Criptococose, Terapia Antirretroviral, Fluconazol, Anfotericina B

Resumo

Introdução: A criptococose é uma micose invasiva, comumente associada à infecção de pacientes HIV+ imunossuprimidos. Objetivo: Caracterizar a clínica e epidemiologia das infecções por Cryptococcus spp. em um hospital de doenças tropicais, nos últimos cinco anos. Método: Trata-se de uma pesquisa descritiva e retrospectiva com abordagem quantitativa. Resultados: Dos 40 pacientes, 90% desenvolveu meningite criptocócica. O exame com tinta nanquim foi positivo em 23 pacientes. O método CrAg foi positivo em 29 pesquisados, sendo o mais utilizado para diagnósticos. A infecção por Cryptococcus foi mais determinante para o desenvolvimento da meningite criptocócica, e a infecção no Sistema Nervoso Central (SNC) foi a forma clínica mais comum. Fluconazol e anfotericina B foram utilizados em mais de 70% dos casos. Conclusão: Visto que metade dos pacientes que vieram a óbito era HIV+, o uso da TARV e rastreamento da infecção fúngica por CrAg pode contribuir para redução da mortalidade dessa população.

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